Cleanroom Shoe Covers & Boot Covers
Cleanroom shoe covers and boot covers are designed to prevent contamination from footwear in controlled environments. These disposable covers act as a barrier, reducing the transfer of particles, dirt, and microorganisms from shoes into cleanrooms. Available in a range of materials and styles, cleanroom shoe covers are used to maintain cleanliness on floors and protect sensitive processes from contamination.
Sterile and non-sterile cleanroom shoe covers are widely used in pharmaceutical, biotechnology, medical device, and laboratory environments. Options such as anti-skid soles, impermeable materials, and high boot styles provide additional protection based on application needs. Whether used in ISO 5 aseptic areas or general cleanroom environments, cleanroom footwear covers are a critical component of contamination control programs and regulatory compliance.
When to Use Each Shoe Cover Type
- Low covers → general cleanroom use
- Boot covers → higher contamination risk areas
- Anti-skid → wet or slippery environments
- Sterile → ISO 5 / aseptic processing
Common Cleanroom Shoe Cover Materials
- Polypropylene (lightweight, economical)
- Microporous (better barrier protection)
- SMS (strong, breathable)
- CPE-coated (fluid resistance)
Cleanroom Shoe Cover Uses by Industry
- Cleanroom shoe covers are used across industries where controlling contamination from footwear is essential to maintaining cleanroom standards and protecting critical processes.
| Industry | Common Use | Why It’s Important |
|---|---|---|
| Pharmaceutical Manufacturing | Worn in cleanrooms, gowning areas, and aseptic zones | Prevents contamination from shoes and supports USP <797>/<800> compliance |
| Biotechnology | Used in labs and production areas | Reduces particle and microbial transfer from personnel |
| Medical Device Manufacturing | Worn in assembly and packaging areas | Maintains product cleanliness and quality standards |
| Compounding Pharmacies | Used in buffer rooms and anterooms | Supports required gowning protocols and contamination control |
| Laboratories | Worn in controlled lab environments | Prevents external contaminants from entering clean areas |
| Semiconductor / Electronics | Used in controlled production areas | Minimizes particle contamination and defects |
- Need to complete your cleanroom garbing requirement? Check out our cleanroom suits, gloves, shoe covers, masks, sleeve protectors, lab coats, goggles, gowns, hoods and other cleanroom apparel to complete your outfit.
Biomedix Sterile Clearnoom Shoe Cover
True Care sterile chemotherapy rated lint-free shoe covers are a very popular option for hospitals and oncology centers that require a lint-free, sterile and chemotherapy-rated shoe cover. This shoe cover is impervious and made from polyethylene coated PET. Serged seams and a flat anti-skid sole make for an economical high-quality sterile shoe cover for ISO5 Class 100 critical areas.
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- Sterile
- Economical
- Impervious
- ISO5 Class 100 rated
- Great for hazardous compounding / oncology
- Chemo-rated
- Flat non-skid sole
- Clean-processed
- Individually packed pairs
- 200 pairs per case, 400pcs
CleanMax Cleanroom Boot Cover
Lakeland CleanMax microporous cleanroom boot covers come sterile or non-sterile, and are clean-processed and individually packed. They are ISO5 Class 100 compatible. Bound seams minimize particle generation and protect from liquid penetration. Easy-open packaging, packed in pairs with boot’s upper folded over so they can be donned touching only the inside of the boot cover.
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- Choose sterile or non-sterile
- ISO4-5 extra-clean processed
- Clean-processed
- Individually packaged pairs
- Sizes: S/M, L/XL, 2XL
- 19″ high, tunneled elastic top
- Non-skid vinyl sole
- Chemo-rated
- 50 pairs per case, 100pcs
Criti Clean CPE Plastic Shoe Cover
Criti Clean CPE plastic shoe covers are water-repellent, lint-free, and come in blue and white colors. They are used when liquid splash protection is important. Many of our customers use the CPE shoe cover as an under-shoe cover when wearing 2 shoe covers for extra protection against contaminants. These polyethylene plastic shoe covers come in cases of 150 pairs available in sizes large and extra-large. These cleanroom shoe covers are very durable and snug fitting. These cross-linked polyethylene shoe covers are not very anti-skid on tile or smooth floors. We offer several brands and types of non-skid shoe covers. We also have a selection of high quality sterile shoe covers.
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- Blue or white color
- Large or extra-large size
- 150 pairs per case
- Cross-linked polyethylene materia
- Lint-free shoe covers
- ISO6 Class 1000+ compatible
- Cost-effective
Criti Clean Polypropylene Anti-Skid Shoe Cover
Criti Clean blue polypropylene shoe covers are lint-free and feature an anti-skid bottom. Our blue shoe covers come in cases of 150 pairs, in sizes large and extra-large. Polypropylene is very breathable and suitable for less strict ISO6 Class 1000+ controlled environments. Our polypropylene shoe covers are high-quality and durable. These are you basic blue shoe covers that you would normally see people wearing in labs, hospitals and healthcare facilities.
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- Blue color
- Large or extra-large size
- 150 pairs per case
- Polypropylene material
- Non-shedding
- ISO6 Class 1000+ compatible
- Economical
CTI SCPL500 Poly Latex Cleanroom Shoe Cover
CT International SCPL500 poly latex shoe covers are uni-size and come in white. The SCPL500 latex shoe covers are are strong, durable, impervious to water, non-skid, and individually inspected. The economical pricing and protectiveness of the plastic material makes them a great staple item for your clean room. These shoe covers are ISO6 Class 1000+ compatible. We offer free samples upon request as well as a best price guarantee.
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- Non-sterile
- Liquid-repelling
- Lint-free
- Liquid and dry particle protection
- Anti-skid bottom
- ISO6 Class 1000 compliant
- Unisize
- 500 pairs, 1000 pcs per case
CTI SCR200 Polyproplyene Blue Shoe Cover
CT International SCR200-NS blue shoe covers are a high-quality basic shoe covers constructed from durable, breathable polypropylene. These overshoes have a white-marked non-skid bottom and come with 200 pcs, 400 pairs per case. This is 50 more pairs per case than other similar cleanroom booties. The SCR200 blue shoe covers are an economical choice in less strict ISO6 Class 1000 and higher controlled environments. Each shoe cover is individually inspected.
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- Blue color
- Non-sterile
- ISO6 Class 1000+ compliant
- Anti-skid bottom
- 200 pair, 400 pcs per case
- XL Size – 18″
- Non-shedding
CTI SCR645 Cleanroom Shoe Cover
CT International SCR645 polyethylene shoe covers are clean-processed making them compatible for ISO5 Class 100 critical environments. Constructed from compressed polyethylene, these lint-free shoe covers offer protection against liquid splash and dry particles. They are breathable, snug-fitting, and feature bound seams. These PE shoe covers are our most economical clean-processed ISO5 Class 100 compliant shoe covers. Choose from a wide variety of sizes: LG (15 inch), XL (17 inch) and 2XL (19 inch).
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- Non-sterile
- Liquid-repelling
- Lint-free
- Anti-skid bottom
- ISO5 Class 100 compliant
- 150 pair, 300pcs per case
- 2XL, XL or LG size options
- Cost-effective
CTI Super Sticky Cleanroom Shoe Covers
CTI SSSC-WHT Class 100 Super Sticky Cleanroom Shoe Covers are engineered for impeccable traction. These super-durable, in-demand high-traction bottom shoe covers ensure stability without compromising comfort. They meet Class 100 cleanroom standards while enduring heavy use. Our customers love these shoe covers, as they are suitable for walking over tacky mats without degrading or tearing. The CTI Class 100 Super Sticky shoe covers elevate safety and efficiency in critical environments and are ideal for industries where secure footing is essential.
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- Non-sterile
- Class 100 compatible
- High-traction bottom
- Liquid-repelling
- Lint-free
- Liquid and dry particle protection
- Unisize
- 150 pairs, 300 pcs per case
DuPont IsoClean Tyvek Cleanroom Boot Cover
DuPont Isoclean Class 100 tyvek cleanroom boot covers are made from authentic clean-processed Tyvek. These are the cleanest boot covers we offer. Comes in sizes medium, large or extra-large. IsoClean Tyvek boot covers are ISO5 Class 100 compatible and come sterile or non-sterile. The patented Gripper non-slip soles offer superior traction even on the slipperiest of floors. Choose from sterile individually packed, non-sterile individually packed and non-sterile bulk packed.
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- Choose sterile or non-sterile
- Clean-processed IsoClean tyvek
- Bulk packed or individually packed
- 50 pair per case, 100pcs
- Superior non-slip bottoms
- White color
- ISO5 Class 100 compatible
- Anti-Static
- Ankle tie with elastic top & ankle for snug, secure fit
- Medium, large and x-large sizing
- Lint-free
DuPont Tyvek Grey Anti-Skid Boot Cover
DuPont anti-skid grey Tyvek boot covers are lint-free and coated with an anti-skid texture. There are 50 pairs of tyvek boot covers per case. These foot covering come bulk packed, non-sterile for use in ISO6 Class 1000 and higher controlled environments. These anti-skid grey tyvek boot covers are 18″ high with elastic top. These shoe covers are a favorite since they are very durable and very anti-skid.
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- Anti-skid coated
- Non-sterile
- Uni-size
- Lint-free Tyvek
- ISO6 Class 1000+ compatible
- Grey color
- 50 pair of boots per case
DuPont Tyvek Grey Anti-Skid Shoe Cover
DuPont anti-skid grey Tyvek shoe covers are lint-free and coated with an anti-skid texture. There are 100 pairs of tyvek shoe covers per case. These foot covering come bulk packed, non-sterile for use in ISO6 Class 1000 and higher controlled environments. These anti-skid grey tyvek shoe covers are 5″ high with elastic top. These shoe covers are a favorite since they are very durable and very anti-skid.
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- Anti-skid coated
- Non-sterile
- Uni-size
- Lint-free Tyvek
- ISO6 Class 1000+ compatible
- Grey color
- 100 pair of shoes per case
FirmGrip Cleanroom Shoe Cover
FirmGrip 3701 and 3703 non-skid shoe covers for cleanroom use are a new high-traction, non-linting shoe cover. Their sticky bottoms make them very effective for use on slippery floors or areas that tend to become slippery. The anti-skid shoe covers are constructed from a multi-layered fabric with a special textured finish added that grips the ground. The elastic top ensures a snug fit for cleanroom worker comfort and safety. They are a higher quality than normal blue polypropylene booties as they are cleaner and more durable. These shoe covers protect against light liquid splash and dry particles. For additional protection, you can use CPE shoe covers under these FirmGrip shoe covers. We also offer a full line of sterile shoe covers.
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- Non-shedding
- Non-sterile
- ISO6 Class 1000+ compliant
- Sticky high-traction non-skid bottom
- Large or extra-large sizes
- White or blue color
- 150 pair, 300pcs per case